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1 The existence of any current psychiatric disease or a history of depression exception. 150mg zoloft The use of any drugs affecting the CNS or PNS other than anti-depressants. Professor Ian Hickie - The University of Sydney The average terminal elimination half-life of plasma sertraline is about 26 hours.

Based on this pharmacokinetic parameter, steady-state sertraline plasma levels should be achieved after approximately one week of once-daily dosing.

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