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Clinical data
PronunciationParacetamol: / ˌ p ær ə ˈ s iː t ə m ɒ l / Acetaminophen: / ə ˌ s iː t ə ˈ m ɪ n ə f ɪ n /  (   listen )
Trade namesTylenol, Panadol, others [2]
License dataUS   FDA: Acetaminophen
Pregnancy categoryAU: A US: C [1] Not tested but seems to be safe
Routes of administrationBy mouth, through the cheek, rectal, intravenous (IV)
ATC codeN02BE01 ( WHO )
Legal status
Legal statusAU: S4 (Rx), OTC, and unscheduled UK: General sales list (GSL, OTC) US: OTC
Bioavailability63–89% [4] : 73
Protein binding10–25% [5]
MetabolismPredominantly in the liver [3]
MetabolitesAPAP gluc, APAP sulfate, APAP GSH, APAP cys, NAPQI [6]
Onset of actionPain relief onset by route: By mouth – 37 minutes [7] Buccal – 15 minutes [7] Intravenous – 8 minutes [7]
Elimination half-life1–4 hours [3]
ExcretionUrine (85–90%) [3]

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Med Clin Worker Am. vol. 1145-59.

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  • Gummin DD, Mowry JB, Spyker DA, Books DE, Is acetaminophen good for hangover KM, Mandate W. 2017 Persistent Report of the Urinary Tract of Total Daily Centers' National Nitrate Data System (NPDS) 35th Inheritor Report. Clin Toxicol (Phila) 2018 Dec. 213-1415. Medline.
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Acetaminophen other namesaller-med, allermax, banophen, benadryl n, compoz, diphen, siladryl, sleep-eze
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