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PMC free article PubMed CrossRef Google Scholar 31. Fleshy Mass Passed Vaginally by a Young Woman - Photo ... Contrarily, it has also been suggested that increased progesterone tissue concentrations are correlated with decreased mitotic activity in normal breast epithelium in women 145 Specifically, treatment with hydro-alcoholic gel provided very limited changes in kal progesterone cream concentrations of estradiol and progesterone but produced markedly different levels of kal progesterone cream accumulation in the breast tissue that was consistent with the treatment eg, higher concentrations of progesterone in the progesterone and estradiol+progesterone groups, and higher concentrations of estradiol in the estradiol and estradiol+progesterone treated groups Mitotic activity was highest in the estradiol-only groups, and lower in the progesterone-only and estradiol+progesterone group, providing evidence that adding 10 13 days of progesterone to estradiol reduced the proliferative effect of estradiol alone 145 However, it is unclear whether the change in progesterone concentrations reflect pharmacologic or physiologic levels during a relevant period of the menstrual cycle 147 One study showed that breast kal progesterone cream proliferation is higher in the luteal than follicular phase characterized by higher serum progesterone relative to estradiol levels 137 At physiologic levels, it is unclear whether this enhanced proliferation is due to progesterone exerting a mitotic effect or a weak antimitotic effect that is insufficient to block the mitotic effect of increased estradiol 147 As such, the association kal progesterone cream progesterone and malignant transformation of breast epithelial cells may be dependent on the levels of estradiol, or other sex steroid hormones.

Hormones exert important effects on proliferation of normal breast epithelium, and therefore, progesterone is a plausible inducer of proliferation in the early phases of breast cancer development.

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