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• GI, cardiac, renal side effects or mixing ibuprofen and excedrin migraine. • COX- 2's not more effective for pain, but better anti-inflammatory, compliance but $$$. These unintentional exposures, reported by the nation s 55 poison control centers, included inadvertent double-dosing, wrong medication taken or given doses given/taken too close together, and inadvertent exposure to someone else s medication, the report said. And, it noted, analgesics were the leading cause of human exposures to potential poisoning at 11.

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